The Department of Endocrinology, 
Use of Gla-100 in Special Situations.
- Senior Consultant Endocrinologist, Providence Endocrine and Diabetes Specialty Center, Trivandrum, Kerala.
- Professor, Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, Tamil Nadu.
- Senior Consultant Endocrinologist, Sudha Hospital and Medical Research Center, Kota, Rajasthan.
- Consultant Endocrinologist, Endocare Superspeciality Hospital, Nizamabad, Telangana.
- Consultant, Apollo Clinic, Howrah, West Bengal.
- Consultant, Department of Internal Medicine, Manipal Hospital, Bangalore, Karnataka.
- Consultant, Dr. Nahata's Clinic, Guwahati, Assam.
- Medical Affairs, Diabetes and Cardiovascular, Sanofi India Ltd., Mumbai, Maharashtra.
- Chairman and Chief Diabetologist, Dr. Mohan's Diabetes Specialities Centre, Chennai, Tamil Nadu.
The Journal of the Association of Physicians of India Vol. 68 · Issue 12[Special] · pp. 60-66
PMID 33247666
Cite This Article
Mathew John, Thomas V Paul, Akhil Joshi, Ravi Kumar, P R Gupta, Shankar Kumar, Kamal Nahata, B K Ravindra, Viswanathan Mohan. Use of Gla-100 in Special Situations. The Journal of the Association of Physicians of India. 2020;68(12[Special]):60-66.
Abstract
Insulin therapy is the cornerstone of diabetes management in people with type 2 diabetes mellitus (T2DM). Therefore, its use is recommended even in special populations and situations such as the elderly, pregnant women, obese individuals, people observing religious fasting, and in the presence of comorbidities such as renal insufficiency, and cancer. Since these special situations predispose to complications such as a high risk of hypoglycemia, patients need constant glucose monitoring and insulin dose adjustments, wherever applicable. This review discusses the various considerations that might guide the decision-making process in the special situations alluded to here. It also throws light on how insulin glargine 100 U/mL has emerged as a preferred choice of insulin therapy in most of these situations, on the strength of its inherently low hypoglycemia and weight gain potential, which has found traction even in the recent diabetes guidelines.
Keywords
- Aged
- Blood Glucose
- Blood Glucose Self-Monitoring
- Diabetes Mellitus
- Type 2
- Dose-Response Relationship
- Drug
- Female
- Glycated Hemoglobin
- Humans
- Hypoglycemic Agents
- Pregnancy
