The Department of Endocrinology, 
Undernutrition-Associated Diabetes Mellitus: Pathophysiology of a Global Problem.
- Global Diabetes Institute, Diabetes Research Center, Department of Endocrinology, Albert Einstein College of Medicine, Bronx, New York, United States.
- Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, Tamil Nadu, India.
- Department of Combined Internal Medicine-Pediatrics (Med-Peds), Stony Brook Medicine, Stony Brook, New York, United States.
- Division of Endocrinology, Diabetes, and Metabolism, Icahn School of Medicine at Mount Sinai, New York, New York, United States.
Physiology (Bethesda, Md.) Vol. 40 · Issue 5
PMID 40049652 DOI 10.1152/physiol.00065.2024
Cite This Article
Pradnyashree Wadivkar, Nihal Thomas, Felix Jebasingh, Valjean Raiden Bacot-Davis, Rohan Maini, Meredith Hawkins. Undernutrition-Associated Diabetes Mellitus: Pathophysiology of a Global Problem. Physiology (Bethesda, Md.). 2025;40(5). doi:10.1152/physiol.00065.2024
Abstract
Early-life undernutrition is known to be a potentially important risk factor for the development of diabetes mellitus in adult life. Additionally, some literature suggests that undernutrition during later life or adulthood may lead to metabolic consequences, including diabetes, despite an individual's normal nutritional status earlier in life. Notably, individuals with diabetes and undernutrition show some unique features that do not fit the usual phenotype of type 2 diabetes mellitus, such as a low body mass index of
Keywords
- insulin deficiency
- insulin secretion
- lean diabetes
- low BMI
- undernutrition
