The Department of Endocrinology, 
Correlation of serum HDL level with HRV indices using multiple linear regression analysis in patients with type 2 diabetes mellitus.
- Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia-KLE International Medical Programme, Belgaum and KLE JGMM Medical College and Hospital, Hubballi, India. Electronic address: drfareedabanu.ab@gmail.com.
- Department of Community Medicine, USM-KLE International Medical Programme, Belgaum, India.
- Department of Physiology, KLE JGMM Medical College and Hospital, Hubballi, India.
- Department of Medicine, USM-KLE International Medical Programme, Belgaum, India.
- Department of Pharmacology, KLE JGMM Medical College and Hospital, Hubballi, India.
- Department of Obstetrics and Gynaecology, USM-KLE International Medical Programme, Belgaum, India.
- Dept. of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India.
- School of Medical Sciences, PPSP USM Kubang Kerian, Malaysia and Deputy Dean USM-KLE International Medical Programme, Belgaum, India. Electronic address: kamarjaalam@usm.my.
Diabetes research and clinical practice Vol. 190 · pp. 109988
PMID 35835257 DOI 10.1016/j.diabres.2022.109988
Cite This Article
Fareedabanu A Balikai, Shivalingappa B Javali, Varsha M Shindhe, Neeta Deshpande, Jyoti M Benni, Darshit P Shetty, Nitin Kapoor, Kamaruddin Jaalam. Correlation of serum HDL level with HRV indices using multiple linear regression analysis in patients with type 2 diabetes mellitus. Diabetes research and clinical practice. 2022;190:109988. doi:10.1016/j.diabres.2022.109988
Abstract
AIMS/OBJECTIVES: To determine the correlation between serum HDL levels with HRV indices in patients with T2DM.
MATERIALS AND METHODS: The study included 120 type 2 DM patients aged 35-65 years of either sex by simple random sampling. One-minute HRV was analyzed during deep breathing and fasting serum HDL levels was estimated in all patients. Data were analyzed using SPSS 20.0. Karl Pearson's correlation coefficient for relationship and Multiple linear regression analysis was applied for assessment of the influence of independent variables (HRV Indices) on a dependent variable (serum HDL levels). P
RESULTS: Significant negative correlation was observed between serum HDL levels with Mean HR (r = 0.7422, p
CONCLUSIONS: Our findings suggest that HDL-C level and all other HRV indices are dependent on each other in patients with T2DM. Most of these patients with low HDL-C level might be associated with autonomic imbalance; this in turn is detected by a simple bedside test of 1-minute HRV during deep breathing.
Keywords
- Autonomic imbalance
- Diabetes mellitus
- HRV indices
- Serum HDL
