The Department of Endocrinology, 
Quantifying Remission Probability in Type 2 Diabetes Mellitus.
- Department of Endocrinology, Bharti Hospital, Karnal 132001, India.
- Department of Endocrinology, St Johns Medical College & Hospital, Bengaluru 560034, India.
- Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore 632004, India.
- Non Communicable Disease Unit, The Nossal Institute for Global Health, Melbourne School of Population and Global Health, University of Melbourne, Victoria 3010, Australia.
- Department of Endocrinology, Osmania Medical College and Hospital, Hyderabad 500095, India.
- Department of Endocrinology, Max Healthcare, New Delhi 110092, India.
- Department of Endocrinology, Nizams Institute of Medical Sciences, Hyderabad 500082, India.
- Department of Endocrinology, Endodiab Clinic, Kozhikode 673016, India.
- Department of Endocrinology, Diabetes and Endocare Clinic, Berhampur 760004, India.
- Department of Endocrinology, CEDAR Diabetes Thyroid & Hormone Clinic Panipat, Panipat 132103, India.
- Department of Endocrinology & Diabetes, Bhaktivedanta Hospital and Research Institute, Mumbai 401107, India.
- Department of Endocrinology, KPC Medical College, Kolkata 700032, India.
- Department of Diabetology, Shilpa Medical Research Centre, Mumbai 400068, India.
- Department of Endocrinology & Medicine, Pondicherry Institute of Medical Sciences, Puducherry 605014, India.
Clinics and practice Vol. 11 · Issue 4 · pp. 850-859
PMID 34842637 DOI 10.3390/clinpract11040100
Cite This Article
Sanjay Kalra, Ganapathi Bantwal, Nitin Kapoor, Rakesh Sahay, Saptarshi Bhattacharya, Beatrice Anne, Raju A Gopal, Sunil Kota, Ashok Kumar, Ameya Joshi, Debmalya Sanyal, Mangesh Tiwaskar, Ashok Kumar Das. Quantifying Remission Probability in Type 2 Diabetes Mellitus. Clinics and practice. 2021;11(4):850-859. doi:10.3390/clinpract11040100
Abstract
Type 2 diabetes mellitus (T2DM) is a chronic progressive disorder and is associated with significant morbidity and mortality. The concept of T2DM remission and the reversal of diabetic parameters to normal levels has been gaining momentum over the past years. T2DM remission is increasingly being recognized by various global guidelines. Multiple models have been developed and validated for quantifying the extent of remission achieved. Based on favorable clinical evidence, T2DM remission can be considered as the therapeutic goal in diabetes management and, in select cases, as an alternative to expensive treatment options, which can be burdensome as T2DM progresses. This narrative review discusses the available strategies, such as lifestyle interventions, physical activity, bariatric surgery, medical nutrition therapy, and non-insulin glucose-lowering medications, for achieving T2DM remission. Although the concept of T2DM remission has emerged as a real-world option, effective implementation in routine clinical practice may not be feasible until long-term studies prove the efficacy of different approaches in this regard.
Keywords
- T2DM remission
- bariatric surgery
- lifestyle interventions
- reversal
- type 2 diabetes mellitus
