The Department of Endocrinology, 
Understanding the predictive accuracy of the InsuTAG index over other surrogate indices in normoglycaemic, non-obese males from Southern India.
- Department of Endocrinology, Diabetes and Metabolism, Christian Medical College Vellore, Ida Scudder Road, Vellore, Tamilnadu, 632004, India.
- Department of Biostatistics, Christian Medical College, Vellore, India.
- Department of Community Health and Development, Christian Medical College, Vellore, India.
- Department of Endocrinology, Diabetes and Metabolism, Christian Medical College Vellore, Ida Scudder Road, Vellore, Tamilnadu, 632004, India. nihal_thomas@cmcvellore.ac.in.
Scientific reports Vol. 13 · Issue 1 · pp. 19497
PMID 37945732DOI 10.1038/s41598-023-45880-z
Cite This Article
Felix K Jebasingh, Shajith Anoop, Riddhi Dasgupta, Mathews Edatharayil Kurian, Aneez Joseph, Grace Rebekah, Venkataraghava Mohan, Nihal Thomas. Understanding the predictive accuracy of the InsuTAG index over other surrogate indices in normoglycaemic, non-obese males from Southern India. Scientific reports. 2023;13(1):19497. doi:10.1038/s41598-023-45880-z
Abstract
We aimed to evaluate the predictive accuracy of InsuTAG index against M value of the hyperinsulinaemic-Euglycaemic clamp (HEC) procedure and fasting surrogate indices of insulin sensitivity/resistance in young, normoglycaemic, Asian Indian males. HEC studies were done in young (mean age 19.7 ± 1 years), non-obese (mean BMI 19.2 ± 2.6 kg/m), normoglycemic Asian Indian males (n = 110) and the M value was calculated. Surrogate indices namely InsuTAG index, HOMA-IR, FG-IR, QUICKI and McAuley index were calculated. Pearson's correlation and ROC-AUC at 95% CI were applied. Significant negative correlation was observed for InsuTAG index with the M value (r - 0.23, p = 0.01), McAuley index (r - 0.65, p
Keywords
- Adolescent
- Humans
- Male
- Young Adult
- Asian People
- Blood Glucose
- Fasting
- Glucose Clamp Technique
- India
- Insulin
- Insulin Resistance
