The Department of Endocrinology, 
Effect of a Peer-led Lifestyle Intervention on Individuals With Normal Weight Obesity: Insights From the Kerala Diabetes Prevention Program.
- Department of Endocrinology, Diabetes, and Metabolism, Christian Medical College & Hospital, Vellore, Tamil Nadu, India
- Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry, and Health Science, The University of Melbourne, Melbourne, Australia. Electronic address: nitin.kapoor@cmcvellore.ac.in.
- Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry, and Health Science, The University of Melbourne, Melbourne, Australia.
- Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry, and Health Science, The University of Melbourne, Melbourne, Australia
- Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
- Centre for Population Health Sciences, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
- Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
- Department of Public Health and Community Medicine, Central University, Kasaragod, Kerala, India.
- The School of Biomedical Engineering and Imaging Sciences, Kings College London, London, United Kingdom
- Centre for Intelligent Healthcare, Faculty of Health and Life Sciences, Coventry University, United Kingdom.
- Department of Endocrinology, Diabetes, and Metabolism, Christian Medical College & Hospital, Vellore, Tamil Nadu, India.
- Department of General Practice, Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, Melbourne, Australia.
Clinical therapeutics Vol. 42 · Issue 8 · pp. 1618-1624
PMID 32718783 DOI 10.1016/j.clinthera.2020.06.007
Cite This Article
Nitin Kapoor, Mojtaba Lotfaliany, Thirunavukkarasu Sathish, Kavumpurathu R Thankappan, Robyn J Tapp, Nihal Thomas, John Furler, Brian Oldenburg. Effect of a Peer-led Lifestyle Intervention on Individuals With Normal Weight Obesity: Insights From the Kerala Diabetes Prevention Program. Clinical therapeutics. 2020;42(8):1618-1624. doi:10.1016/j.clinthera.2020.06.007
Abstract
PURPOSE: Normal weight obesity (NWO) is a unique phenotype of obesity associated with high cardiovascular mortality. There is limited literature on assessing the effect of therapeutic interventions on the cardiometabolic health of these individuals. We studied the effect of a peer-led lifestyle intervention on key cardiometabolic parameters (blood glucose, blood pressure, and plasma lipids) in individuals with NWO.
METHODS: This study is a secondary data analysis of the Kerala Diabetes Prevention Program, a cluster-randomized controlled study that involves a peer-led, real-life lifestyle intervention for individuals from the community between the ages of 30 and 60 years with a high diabetes risk. Participants underwent a rigorous cardiometabolic evaluation at baseline and at 2-year follow-up.
FINDINGS: A total of 292 recruited individuals with NWO were randomized into the intervention (n = 159) and control (n = 133) arms. At 2 years of follow-up, there was minimal but statistically significant improvement in systolic blood pressure and serum HDL level in the intervention arm, but no statistical difference was seen in other lipid and glycemic parameters.
IMPLICATIONS: This study provides early evidence of the effect of a lifestyle intervention in a cohort of individuals with NWO. Only systolic blood pressure and serum HDL level had a mild favorable change in the intervention arm when compared with the control arm.
Keywords
- South Asian phenotype
- lifestyle intervention
- normal weight obesity
- thin-fat phenotype
