The Department of Endocrinology, 
Exocrine pancreatic insufficiency related fat malabsorption and its association with autonomic neuropathy in Asian Indians with type 2 diabetes mellitus.
- Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India.
- Department of Biostatistics, Christian Medical College, Vellore, India.
- Division of Gastrointestinal Sciences, Wellcome Research Laboratory, Christian Medical College, Vellore, India.
- Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India. Electronic address: nihal_thomas@cmcvellore.ac.in.
Diabetes & metabolic syndrome Vol. 15 · Issue 5 · pp. 102273
PMID 34520998 DOI 10.1016/j.dsx.2021.102273
Cite This Article
Shajith Anoop, Riddhi Dasgupta, Felix K Jebasingh, Roshna Ramachandran, Mathews Edatharayil Kurian, Grace Rebekah, K A Balsubramanian, Nihal Thomas. Exocrine pancreatic insufficiency related fat malabsorption and its association with autonomic neuropathy in Asian Indians with type 2 diabetes mellitus. Diabetes & metabolic syndrome. 2021;15(5):102273. doi:10.1016/j.dsx.2021.102273
Abstract
BACKGROUND AND AIMS: We aimed to estimate the prevalence of exocrine pancreatic insufficiency (EPI) related fat malabsorption & to correlate it with measures of autonomic neuropathy in patients with T2DM from India.
METHODS: Patients with T2DM (cases; n = 118) and normo-glycaemic individuals (controls; n = 82) underwent anthropometry and biochemical evaluation at baseline. The 72-hours fecal fat excretion was estimated by the Van de Kamer's titration method. Autonomic neuropathy was evaluated using an automated analyzer.
RESULTS: The prevalence of EPI related fat malabsorption in cases was 45% (n = 53; 72 hours mean fecal fat level = 22.7 ± 5.6 g/day). Dysfunctions in the parasympathetic nervous system (PNS; 86.7%; p
CONCLUSION: In this cross-sectional cohort of Asian Indian patients with T2DM (n = 118), EPI related fat malabsorption correlates significantly with autonomic dysfunction in patients with T2DM. However, these preliminary data need to confirmed in trials with more robust design.
Keywords
- 72 h fecal Fat assay
- Asian indians
- Autonomic dysfunction
- Exocrine pancreatic insufficiency
- Fat malabsorption
- Type 2 diabetes mellitus
