The Department of Endocrinology, 
Paget’s Disease of Bone: An Entity Still Exists in India.
- Department of Endocrinology, Christian Medical College, Vellore, Tamil Nadu, India.
- Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
- Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India.
Indian journal of endocrinology and metabolism Vol. 22 · Issue 3 · pp. 368-372
PMID 30090729 DOI 10.4103/ijem.ijem_19_18
Cite This Article
Kripa Elizabeth Cherian, Nitin Kapoor, Sahana Shetty, Felix K Jebasingh, Hesarghatta Shyamasunder Asha, Julie Hephzibah, Anne Jennifer Prabhu, Simon Rajaratnam, Nihal Thomas, Thomas Vizhalil Paul. Paget’s Disease of Bone: An Entity Still Exists in India. Indian journal of endocrinology and metabolism. 2018;22(3):368-372. doi:10.4103/ijem.ijem_19_18
Abstract
BACKGROUND: Paget's disease of bone (PDB) is uncommonly reported from India. We attempted to study the clinical and imaging features and management of participants who presented with PDB.
MATERIALS AND METHODS: In this retrospective study, clinical and imaging profile, biochemistry, and treatment outcomes of participants with PDB ( = 48) were obtained.
RESULTS: The mean age was 60 ± 11.3 years and 35% were women. Twenty percent were asymptomatic. Many (87%) had polyostotic involvement. Sixty percent ( = 29) underwent treatment with zoledronic acid and rest with oral bisphosphonates, and all achieved remission.
CONCLUSION: Most of the pagetic participants had polyostotic disease and one-fifth were asymptomatic. All participants had disease remission following treatment.
Keywords
- Bisphosphonates
- India
- Paget's disease of bone
- polyostotic disease
- zoledronic acid
