The Department of Endocrinology, 
New-Onset Diabetes Mellitus in COVID-19: A Scoping Review.
- Department of Diabetes, Nutrition and Metabolic Diseases, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
- Doctoral School, "Carol Davila" University of Medicine and Pharmacy, 020021, Bucharest, Romania.
- Doctoral School, "Carol Davila" University of Medicine and Pharmacy, 020021, Bucharest, Romania. ioana-cristina.bica@drd.umfcd.ro.
- Heart and Vascular Institute, Cleveland Clinic, Abu Dhabi, United Arab Emirates.
- Medical Research Center, Sultan Qaboos University, Muscat, Oman.
- Department of Training and Studies, Royal Hospital, Ministry of Health, Muscat, Oman.
- Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland.
- Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
- Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland.
- Department of Biochemistry, Mohamed Bin Rashid University, Dubai, United Arab Emirates.
- IRCCS MultiMedica, Milan, Italy.
- Clinic of Endocrinology, Ankara Güven Hospital, Ankara, Turkey.
- Unit of Cardiology, Karolinska Institute and Karolinska University Hospital, University of Stockholm, Stockholm, Sweden.
- Unit of Research and International Cooperation, University Hospital of Palermo, Palermo, Italy.
- Department of Biomedicine, Neurosciences and Advanced Diagnostics (Bind), University of Palermo, Palermo, Italy.
- Department of Endocrinology, Singapore General Hospital, Singapore, Singapore.
- Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia.
- Department of Endocrinology, Bharti Hospital and Bride, Karnal, India.
- Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India.
- Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
- Department of Medicine and Oncology, Semmelweis University, Budapest, Hungary.
- The Research Institute, Imperial College London Diabetes Centre, Abu Dhabi, United Arab Emirates.
- Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, Sao Paulo, Brazil.
- Department of Clinical Biochemistry, Royal Free Hospital Campus, University College London Medical School, University College London (UCL), London, UK.
- Dental Institute, Periodontology Unit, Centre for Host-Microbiome Interactions, King's College London, London, UK.
- Diabetes Center, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
- Social Determinants of Obesity and Cardiovascular Risk Laboratory, Cardiovascular Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
- Department of Medicine, University of Central Florida College of Medicine, Orlando, FL, USA.
- Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
- Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sci-Ences, Mashhad, Iran.
- Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
- Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil.
- Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
- Cicarrone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medi-Cine, Baltimore, MD, USA.
- Diabetes Research Centre, Chennai, India.
- Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMise), School of Medicine, University of Palermo, Palermo, Italy.
Diabetes therapy : research, treatment and education of diabetes and related disorders Vol. 15 · Issue 1 · pp. 33-60
PMID 37751143 DOI 10.1007/s13300-023-01465-7
Cite This Article
Anca Pantea Stoian, Ioana-Cristina Bica, Teodor Salmen, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Alberto Firenze, Massimo Galia, Su-Yen Goh, Andrej Janez, Sanjay Kalra, Nitin Kapoor, Peter Kempler, Nader Lessan, Paulo Lotufo, Dimitri P Mikhailidis, Luigi Nibali, Nikolaos Papanas, Tiffany Powell-Wiley, Ali A Rizvi, Amirhossein Sahebkar, Raul D Santos, Peter P Toth, Vijay Viswanathan, Manfredi Rizzo. New-Onset Diabetes Mellitus in COVID-19: A Scoping Review. Diabetes therapy : research, treatment and education of diabetes and related disorders. 2024;15(1):33-60. doi:10.1007/s13300-023-01465-7
Abstract
INTRODUCTION: The coronavirus disease 2019 (COVID-19) pandemic became superimposed on the pre-existing obesity and diabetes mellitus (DM) pandemics. Since COVID-19 infection alters the metabolic equilibrium, it may induce pathophysiologic mechanisms that potentiate new-onset DM, and we evaluated this issue.
METHOD: A systematic review of the literature published from the 1 January 2020 until the 20 July 2023 was performed (PROSPERO registration number CRD42022341638). We included only full-text articles of both human clinical and randomized controlled trials published in English and enrolling adults (age > 18 years old) with ongoing or preceding COVID-19 in whom hyperglycemia was detected. The search was based on the following criteria: "(new-onset diabetes mellitus OR new-onset DM) AND (COVID-19) AND adults".
RESULTS: Articles on MEDLINE (n = 70) and the Web of Science database (n = 16) were included and analyzed by two researchers who selected 20 relevant articles. We found evidence of a bidirectional relationship between COVID-19 and DM.
CONCLUSIONS: This link operates as a pathophysiological mechanism supported by epidemiological data and also by the clinical and biological findings obtained from the affected individuals. The COVID-19 pandemic raised the incidence of DM through different pathophysiological and psychosocial factors.
Keywords
- Coronavirus disease 2019
- Diabetes mellitus
- Hyperglycemia
- New-onset diabetes
- New-onset hyperglycemia
- Newly diagnosed diabetes
- Prediabetes
- Severe acute respiratory syndrome coronavirus-2 infection
