The Department of Endocrinology, 
Hyperprolactinemia Due to Prolactinoma has an Adverse Impact on Bone Health with Predominant Impact on Trabecular Bone: A Systematic Review and Meta-Analysis.
- Department of Endocrinology, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, India.
- Department of Endocrinology, Center for Endocrinology, Diabetes, Arthritis & Rheumatism (CEDAR) Super-speciality Healthcare, Dwarka, New Delhi, India. Electronic address: deepdutta2000@yahoo.com.
- Department of Endocrinology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India.
- Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore India
- The Non-Communicable Disease Unit, Baker Heart and Diabetes Institute, Melbourne, Australia.
- Department of Endocrinology, Bhaktivedanta Hospital and Research Institute, Mumbai, Maharashtra, India.
- Department of Endocrinology, Indraprastha Apollo Hospitals, New Delhi, India.
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry Vol. 27 · Issue 1 · pp. 101453
PMID 38064881 DOI 10.1016/j.jocd.2023.101453
Cite This Article
Lakshmi Nagendra, Deep Dutta, Sunetra Mondal, Nitin Kapoor, Ameya Joshi, Saptarshi Bhattacharya. Hyperprolactinemia Due to Prolactinoma has an Adverse Impact on Bone Health with Predominant Impact on Trabecular Bone: A Systematic Review and Meta-Analysis. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry. 2024;27(1):101453. doi:10.1016/j.jocd.2023.101453
Abstract
BACKGROUND: No meta-analysis has holistically analysed and summarized the effect of prolactin excess due to prolactinomas on bone mineral metabolism. We undertook this meta-analysis to address this knowledge-gap.
METHODS: Electronic databases were searched for studies having patients with hyperprolactinemia due to prolactinoma and the other being a matched control group. The primary outcome was to evaluate the differences in BMD Z-scores at different sites. The secondary outcomes of this study were to evaluate the alterations in bone mineral density, bone mineral content and the occurrence of fragility fractures.
RESULTS: Data from 4 studies involving 437 individuals was analysed to find out the impact of prolactinoma on bone mineral metabolism. Individuals with prolactinoma had significantly lower Z scores at the lumbar spine [MD -1.08 (95 % CI: -1.57 - -0.59); P
Keywords
- Bone microarchitecture
- Bone mineral density
- Fractures
- Meta-analysis
- Prolactin
