The Department of Endocrinology, 
Hypovitaminosis D and bone mineral density in human immunodeficiency virus-infected men from India, with or without antiretroviral therapy.
- Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India. thomasvpaul@yahoo.com
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Vol. 16 · Issue 4 · pp. 547-53
PMID 20150027 DOI 10.4158/ep09197.or
Cite This Article
Thomas Vizhalil Paul, Hesarghatta Shyamasunder Asha, Nihal Thomas, Mandalam Subramanian Seshadri, Priscilla Rupali, Ooriapadickal Cherian Abraham, Susanne Alexander Pulimood, Arun Jose. Hypovitaminosis D and bone mineral density in human immunodeficiency virus-infected men from India, with or without antiretroviral therapy. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2010;16(4):547-53. doi:10.4158/ep09197.or
Abstract
OBJECTIVE: To study the vitamin D status and bone mineral density (BMD) in men infected with human immunodeficiency virus (HIV) in a tertiary care center from southern India.
METHODS: We conducted a cross-sectional study of 35 HIV-infected men (between 20 and 50 years old) receiving highly active antiretroviral therapy (HAART) (group 1) in comparison with 35 age- and body mass index-matched HIV-positive antiretroviral therapy-naïve men (group 2) and 35 HIV-negative healthy control subjects (group 3).
RESULTS: A significantly greater proportion (P = .002) of patients (74%) in the HAART group had vitamin D deficiency (
CONCLUSION: A significant proportion of patients receiving HAART had vitamin D deficiency. The secondary hyperparathyroidism probably due to vitamin D deficiency is an important contributing factor for the observed changes in BMD. Vitamin D deficiency noted in this group is probably multifactorial, and further research is needed to determine whether the effect of HAART on vitamin D metabolism is an additional causative factor and what benefit vitamin D supplementation might confer in these patients.
Keywords
- Adult
- Aging
- Antiretroviral Therapy
- Highly Active
- Body Mass Index
- Bone Density
- Cross-Sectional Studies
- Diet
- Femur Neck
- HIV Infections
- Humans
- India
- Male
- Middle Aged
- Nutritional Status
- Parathyroid Hormone
- Prevalence
- Sunlight
- Vitamin D Deficiency
- Young Adult
