The Department of Endocrinology, 
A common variant in the FTO locus is associated with waist-hip ratio in Indian adolescents.
- Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine & Surgery, Karolinska Institutet, Stockholm, Sweden. vasan.kandaswamy@ki.se
Pediatric obesity Vol. 8 · Issue 3 · pp. e45-9
PMID 23447422 DOI 10.1111/j.2047-6310.2013.00118.x
Cite This Article
S K Vasan, T Fall, V Job, H F Gu, E Ingelsson, K Brismar, F Karpe, N Thomas. A common variant in the FTO locus is associated with waist-hip ratio in Indian adolescents. Pediatric obesity. 2013;8(3):e45-9. doi:10.1111/j.2047-6310.2013.00118.x
Abstract
BACKGROUND: Common variants in the FTO locus, and near MC4R locus, have been shown to have a robust association with obesity in children and adults among various ethnic groups. Associations with obesity traits among Indian adolescents have not been determined.
OBJECTIVE: To study the association of rs9939609 (FTO) and rs17782313 (MC4R) to obesity related anthropometric traits in Indian adolescents.
METHODS: Subjects for the current study were recruited from a cross-sectional cohort of 1,230 adolescents (age mean ± SD: 17.1 ± 1.9 years) from South India.
RESULTS: The variant at the FTO locus was found to be associated with waist-hip ratio (WHR) but not with overall obesity in this population. No significant association was observed for obesity-traits and Mc4R variant rs17782313.
CONCLUSION: The common variant of FTO (rs9939609) is associated with body fat distribution during early growth in Indian adolescents and may predispose to obesity and metabolic consequences in adulthood.
Keywords
- Adolescent
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO
- Body Mass Index
- Cross-Sectional Studies
- Diet
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- India
- Male
- Obesity
- Phenotype
- Proteins
- Receptor
- Melanocortin
- Type 4
- Waist-Hip Ratio
