The Department of Endocrinology, 
Bone Health and Impact of Tenofovir Treatment in Men with Hepatitis-B Related Chronic Liver Disease.
- Professor, Department of Hepatology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
- Associate Professor, Department of Endocrinology, Diabetes and Metabolism, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
- Assistant Professor, Department of Endocrinology, Diabetes and Metabolism, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
- Professor & Head, Department of Hepatology, Christian Medical College and Hospital, Tamil Nadu, India.
- Professor, Department of Endocrinology, Diabetes and Metabolism, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Journal of clinical and experimental hepatology Vol. 8 · Issue 1 · pp. 23-27
PMID 29743793 DOI 10.1016/j.jceh.2017.05.009
Cite This Article
Kattiparambil G Sajith, Nitin Kapoor, Sahana Shetty, Ashish Goel, Uday Zachariah, Chundamannil E Eapen, Thomas V Paul. Bone Health and Impact of Tenofovir Treatment in Men with Hepatitis-B Related Chronic Liver Disease. Journal of clinical and experimental hepatology. 2018;8(1):23-27. doi:10.1016/j.jceh.2017.05.009
Abstract
BACKGROUND: Chronic Liver Disease (CLD) has been shown to have an adverse impact on bone health. Hepatitis-B related CLD and its treatment with tenofovir may have additional effects on skeleton.
OBJECTIVE: To study the impact of HBV related CLD and its treatment with Tenofovir on bone health in Indian subjects.
METHODS: This cross sectional study included men (18-60 years) and comprised of three groups: Group-1 was treatment naïve HBV related CLD ( = 79), Group-2 those with HBV related CLD on tenofovir for at least 1 year ( = 136), Group-3 age, sex and Body Mass Index (BMI) matched healthy controls ( = 58). Bone biochemistry and Bone Mineral Density (BMD) at spine, Femoral Neck (FN) and forearm were studied. Independent -test or ANOVA was used to compare the means of continuous variables and chi-square test for categorical variables. Multiple logistic regression was used to assess the factors causing Low Bone Mass (LBM) at FN.
RESULTS: A significantly greater proportion (
CONCLUSION: The impact of hepatitis-B related CLD as well as its treatment on bone health is significant. Bone health need to be periodically evaluated in these subjects especially in older men who are lean and have a higher viral load.
Keywords
- BMI
- Body Mass Index
- CLD
- Chronic Liver Disease
- FN
- Femoral Neck
- LBM
- Low Bone Mass
- bone mineral density
- chronic liver disease
- hepatitis-B
- tenofovir
