The Department of Endocrinology, 
Hyperaldosteronism secondary to renal agenesis: An unusual cause for hypertension in pregnancy.
- Department of Medicine, Christian Medical College, Vellore, Tamil Nadu, India. Electronic address: nalini.newbigging@cmcvellore.ac.in.
- Department of Medicine, Christian Medical College, Vellore, Tamil Nadu, India
- Medicine Unit 3 and Obstetric Medicine, Vellore, Tamil Nadu, India. Electronic address: sowmya@cmcvellore.ac.in.
- Medicine Unit 3 and Obstetric Medicine, Vellore, Tamil Nadu, India. Electronic address: sudhajasmine@cmcvellore.ac.in.
- Obstetrics and Gynaecology Unit 4, Vellore, Tamil Nadu, India. Electronic address: Liji.David@cmcvellore.ac.in.
- Department of Medicine 3 and Obstetric Medicine, Vellore, Tamil Nadu, India. Electronic address: audrinlenin@cmcvellore.ac.in.
- Department of Medicine 3 and Obstetric Medicine, Vellore, Tamil Nadu, India. Electronic address: jennifer.david.pg@cmcvellore.ac.in.
- Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, Tamil Nadu, India. Electronic address: nihal_thomas@cmcvellore.ac.in.
- Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, Tamil Nadu, India. Electronic address: remya.rajan@cmcvellore.ac.in.
- Department of Nephrology Christian Medical College, Vellore, Tamil Nadu, India. Electronic address: suceena@cmcvellore.ac.in.
Pregnancy hypertension Vol. 38 · pp. 101157
PMID 39244817 DOI 10.1016/j.preghy.2024.101157
Cite This Article
Nalini Newbigging, Sowmya Sathyendra, Sudha Jasmine, Liji S David, Audrin Lenin, Jennifer David Livingstone, Nihal Thomas, Remya Rajan, Suceena Alexander. Hyperaldosteronism secondary to renal agenesis: An unusual cause for hypertension in pregnancy. Pregnancy hypertension. 2024;38:101157. doi:10.1016/j.preghy.2024.101157
Abstract
Literature with regards to pregnancy related outcomes in persons with the presence of a solitary kidney of any cause is scarce. Most of the available information has been extrapolated from persons who have been renal donors. Unilateral renal agenesis affects 1 in 1500 people and can present with resistant hypertension. When a woman with a solitary kidney presents in pregnancy, it may be both a challenging diagnostic and therapeutic problem. Eplerenone, a selective aldosterone blocker has been prescribed for resistant hypertension and in the presence of pregnancy, been useful in persons with primary hyperaldosteronism and resistant hypertension due to obstructive sleep apnoea. We describe the use of Eplerenone in a patient with resistant hypertension in pregnancy, due to secondary hyperaldosteronism precipitated by renal agenesis.
Keywords
- Eplerenone
- Pregnancy
- Renal agenesis
- Resistant hypertension
- Secondary hyperaldosteronism
